Janina Niggenaber, Dr. rer. nat.
Position: Postdoc
Room no.: CP-02-114
Telephone no.: +49 231 755 7052
Member of the group since: 12/2017
University degree: Dr. rer. nat. in Chemical Biology, TU Dortmund University
Expertise: protein expression, purification and crystallization
Off-Lab activities (hobbies): music, playing guitar, meeting friends
Research projects:
Mutants of the ErbB receptor tyrosine kinase family, such as EGFR-T790M, EGFR-C797S and also the insertion mutants of EGFR and HER2, play important roles in the development of NSCLC. Therefore, these proteins are attractive targets in the targeted therapy, which demonstrate a alternative treatment in addition to chemotherapy. The main aim of the medicinal chemistry is the development of effective small molecules to inhibit these cancer-relevant mutants. For the structure-based design approach the protein crystallization represents the most important step of the structure determination. The gained knowledge about the binding mode and the orientation in the binding pocket forms the basis for the iterative development cycle of this inhibitors.
Earlier positions:
Bachelor and Master studies in the group of Daniel Rauh based on protein expression, purification and crystallization
Publications:
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Lategahn, J.; Hardick, J.; Grabe, T.; Niggenaber, J.; Jeyakumar, K.; Keul, M.; Tumbrink, H. L.; Becker, C.; Hodson, L. Kirschner, T.; Klövekorn, P.; Ketzer, J.; Baumann, M.; Terheyden, S.; Unger, A.; Weisner, J.; Müller, M. P.; van Otterlo, W. A. L.; Bauer, S.; Rauh, D.. Targeting Her2-insYVMA with Covalent Inhibitors-A Focused Compound Screening and Structure-Based Design Approach. J. Med. Chem. 2020, 63 (20), 11725–11755.
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Niggenaber, J.; Hardick, J.; Lategahn, J.; Rauh, D.. Structure Defines Function: Clinically Relevant Mutations in ErbB Kinases. J. Med. Chem. 2020, 63 (1), 40–51.
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Lategahn, J.; Keul, M.; Klövekorn, P.; Tumbrink, H. L.; Niggenaber, J.; Müller, M. P.; Hodson, L.; Flaßhoff, M.; Hardick, J.; Grabe, T.; Engel, J.; Schultz-Fademrecht, C.; Baumann, M.; Ketzer, J.; Mühlenberg, T.; Hiller, W.; Günther, G.; Unger, A.; Müller, H.; Heimsoeth, A.; Golz, C.; Blank-Landeshammer, B.; Kollipara, L.; Zahedi, R. P.; Strohmann, C.; Hengstler, J. G.; van Otterlo, W. A. L.; Bauer, S.; Rauh, D.. Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S. Chem. Sci. 2019, 10 (46), 10789–10801.