Prof. Dr. Daniel Rauh
Position/function: Full Professor
Room no.: CP-02-135
Telephone no.: +49 (0)231 755 7080
Email: daniel.rauh@tu-dortmund.de
University degree: Univ. Prof. for Medicinal Chemistry and Chemical Biology (Full Professorship)
Curriculum Vitae
Professional Summary:
Experienced research leader specializing in Chemical Biology, Medicinal Chemistry, and targeted cancer therapies, with a focus on covalent and allosteric modulation of targets. Expertise includes protein X-ray crystallography, structure-based drug design, and translating academic research into pharmaceutical applications.
Education:
06/1993
Abitur, Peter-Petersen-Schule, Hamburg
07/1993 – 10/1994
Military Service, Bundesmarine, Flensburg
10/1994 – 07/1998
Pharmacy, Ernst-Moritz-Arndt University, Greifswald, Germany
07/1999
Dipl.-Pharm. and Approbation pharmacist (Apotheker)
01/2000 – 12/2002
Ph.D. thesis on "Trypsin Mutants for Structure-Based Drug Design" under Gerhard Klebe, Phillips-University Marburg, Germany. Achieved "summa cum laude".
Research and Academic Positions:
01/2003 – 03/2004
Postdoc with Milton Stubbs, Martin-Luther-Universität Halle-Wittenberg, Germany
04/2004 – 04/2006
Postdoc with Kevan Shokat, HHMI, UCSF, San Francisco, USA
04/2006 – 10/2010
Independent Group Leader, Chemical Genomics Centre, Max Planck Society, Dortmund, Germany
11/2010 – 07/2013
W2 Professor for Chemical Biology and Biochemistry, TU Dortmund University, Germany
08/2013 – present
W3 Professor and Chair for Medicinal Chemistry and Chemical Biology, TU Dortmund University, Germany
Awards:
2010
Innovation-Prize for Medicinal and Pharmaceutical Chemistry, German Chemical Society (GDCh)
2013
Novartis Early Career Award in Organic Chemistry
2015
Prize of the Monika Kutzner Foundation for Cancer Research
2017
Prize of the Mercator Research Center Ruhr
2020
Barry Cohen Prize of the Israel Chemical Society
Professional Activities:
2012 – 2021
Associate Editor, ACS Chemical Biology
2014
Co-founder, Zentrum für integrierte Wirkstoffforschung (ZIW), TU Dortmund University
2015 – present
Chair of the selection committee of the Klaus-Grohe Prize in Medicinal Chemistry, German Chemical Society (GDCh)
2016 – 2022
Vice Dean, Department of Chemistry and Chemical Biology
2018
Initiator and coordinator of the "Drug Discovery Hub Dortmund (DDHD)", TU Dortmund University
2017 – 2024
Chair, local chapter Dortmund, German Chemical Society (GDCh)
Entrepreneurial Activities:
2019
Co-founded PearlRiver Bio GmbH Dortmund (sold to Centessa in 2021). PearlRiver Bio focused on developing next-generation covalent EGFR inhibitors for non-small cell lung cancer.
2024
Co-founded KyDo Therapeutics GmbH Dortmund. KyDo Therapeutics specializes in developing covalent-allosteric inhibitors, unlocking the full potential of targeting the PI3K/Akt pathway to treat severe human diseases.