Team
Team

Shivakrishna Kallepu

Position: Postdoctoral Fellow

Room no.: CP-02-112

Telephone no.: +49 231 755 7056

Member of the group since: 07/2019

University Degree: Dr. rer. nat. in Chemistry (Research Supervisor: Dr. S. Chandrasekhar, CSIR-IICT)

Expertise: Organic synthesis, transition-metal catalysis, natural products chemistry.

Off-Lab activities (hobbies): Listening to music, playing chess, reading.

Research projects:

The majority of commercial fragment libraries mainly consists of flat sp2-structures, which necessarily address a limited spectrum of the chemical space. Hence, structures with 3D-architecture remain in high demand due to their given complementarity to putative protein targets. So, my current project involves in design and synthesis of sp3-rich fragment library. This library will be screened employing protein X-ray crystallography to identify fragment hits that potentially can be grown and optimized by chemical modification to generate lead-structure ultimately.

 

Curriculum Vitae:

Master studies in organic chemistry at the NIT-Warangal and Bachelor degree from Kakatiya University.

 

Publications:

  1. Kallepu, S.; Neeli, P. K.; Mallappa, S.; Nagendla, N. K.; Reddy Mudiam, M. K.; Mainkar, P. S.; Kotamraju, S.; Chandrasekhar, S.. sp3 -Rich Glycyrrhetinic Acid Analogues Using Late-Stage Functionalization as Potential Breast Tumor Regressing Agents. ChemMedChem 2020, 15 (19), 1826–1833.

    DOI PubMed

  2. Goli, N.; Kallepu, S.; Mainkar, P. S.; Lakshmi, J. K.; Chegondi, R.; Chandrasekhar, S.. Synthetic Strategy toward the Pentacyclic Core of Melodinus Alkaloids. J. Org. Chem. 2018, 83 (4), 2244–2249.

    DOI PubMed

  3. Kallepu, S.; Kavitha, M.; Yeeravalli, R.; Manupati, K.; Jadav, S. S.; Das, A.; Mainkar, P. S.; Chandrasekhar, S.. Total Synthesis of Desmethyl Jahanyne and Its Lipo-Tetrapeptide Conjugates Derived from Parent Skeleton as BCL-2-Mediated Apoptosis-Inducing Agents. ACS Omega 2018, 3 (1), 63–75.

    DOI PubMed

  4. Kallepu, S.; Sanjeev, K.; Chegondi, R.; Mainkar, P. S.; Chandrasekhar, S.. Benzyne Insertion onto β-Keto Esters of Polycyclic Natural Products: Synthesis of Benzo Octacyclo Scaffolds. Org. Lett. 2018, 20 (22), 7121–7124.

    DOI PubMed

  5. Anitha, P. M.; Mainkar, P. S.; Kallepu, S.; Babu, V. S. P.; Reddy, C. S.; Chandrasekhar, S.. Caveat in the stereochemical outcome of the organocatalytic Diels–Alder reaction in PEG-400. RSC Adv. 2016, 6 (80), 76132–76136.

    DOI

  6. Gollapelli, K. K.; Kallepu, S.; Govindappa, N.; Nanubolu, J. B.; Chegondi, R.. Carbonyl-assisted reverse regioselective cascade annulation of 2-acetylenic ketones triggered by Ru-catalyzed C-H activation. Chem, Sci. 2016, 7 (7), 4748–4753.

    DOI PubMed

  7. Kallepu, S.; Gollapelli, K. K.; Nanubolu, J. B.; Chegondi, R.. Synthesis of highly strained bicyclic3.n.1alkenes by a metal-catalyzed Conia-ene reaction. Chem. Commun. 2015, 51 (94), 16840–16843.

    DOI PubMed