Team
Team

Rajesh Gontla, Ph.D.

Position: Postdoctoral fellow

Room no.: CP-02-112

Telephone no.: +49 231 755 7056

Member of the group: 04/2013 – 08/2015 and 09/2017-till today

University degree: Dr. rer. nat. in Chemistry

 

Expertise: Organic synthesis

Off-Lab activities (hobbies): Playing Badminton and Chess, Music and Cooking.

Research projects:

Activating mutations in KRAS are found to be the most common mutations in various types of cancers. In particular, KRASG12C mutation is observed in most of the cancers. Various approaches are there to lock the KRAS in the inactive state but not reaches the affinity of GTP/GDP levels which is the major drawbacks of this area.  Even though the efforts of various research groups and industries across the globe from the last couple of decades to till date, there is no potent small molecule inhibitors are available for KRAS.  In this project we strongly focus on the Structure based drug design, synthesis of novel nucleotide competitive covalent inhibitors and evaluation in cellular viability assays.

 

Earlier Positions:

Since 09/2017

Post-Doctoral Researcher, Technische Universität-Dortmund, Germany.  

"Design and synthesis of Nucleotide competitive inhibitors for the KRAS."

Principal Investigator: Prof. Dr. Daniel Rauh

09/2015- 08/2017

Post-Doctoral Researcher, Max-Planck Institute of Molecular Physiology -Dortmund, Germany.

"Synthesis of novel chiral Cp-Rh complexes and their potential applications in asymmetric catalysis."

Principal Investigator: Prof. Dr. Herbert Waldmann

04/2013 - 07/2015 (>2 years)  

Post-Doctoral Researcher, Technische Universität-Dortmund, Germany.

"Design and synthesis of small molecules as Covalent-Allosteric Akt inhibitors (CAAI’s)"

Principal Investigator: Prof. Dr. Daniel Rauh

10/2011 -03/2013 (1.5 years)

Senior Research Associate, Chemveda Life Sciences Pvt Ltd., Hyderabad, India. Process research and development (Process R&D) and CRO projects in Synthetic organic and medicinal chemistry.

06/2005 - 06/2006 (1 year)

Organic Chemistry Lecturer, NNS Vidya P.G College, Chirala, India.

"Organic Spectroscopy, Named reactions and reaction mechanism, Disconnection approach, Symmetry and Group theory."

(05/2002 -05/2003 (1 year)

Research Chemist, Divi’s Laboratories, Hyderabad, India.

"Maintaining High Vacuum Distillation plants and Vacuum tray dryers in bulk scale quantities."

Maintaining the BPR and MPR records for Q.A department.

 

Publications:

  1. Uhlenbrock, N.; Smith, S.; Weisner, J.; Landel, I.; Lindemann, M.; Le, T. A.; Hardick, J.; Gontla, R.; Scheinpflug, R.; Czodrowski, P.; Janning, P.; Depta, L.; Quambusch, L.; Müller, M. P.; Engels, B.; Rauh, D.. Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem. Sci. 2019, 10 (12), 3573–3585.

    DOI PubMed

  2. Weisner, J.; Landel, I.; Reintjes, C.; Uhlenbrock, N.; Trajkovic-Arsic, M.; Dienstbier, N.; Hardick, J.; Ladigan, S.; Lindemann, M.; Smith, S.; Quambusch, L.; Scheinpflug, R.; Depta, L.; Gontla, R.; Unger, A.; Müller, H.; Baumann, M.; Schultz-Fademrecht, C.; Günther, G.; Maghnouj, A.; Müller, M. P.; Pohl, M.; Teschendorf, C.; Wolters, H.; Viebahn, R.; Tannapfel, A.; Uhl, W.; Hengstler, J. G.; Hahn, S. A.; Siveke, J. T.; Rauh, D.. Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer. Cancer Res. 2019, 79 (9), 2367–2378.

    DOI PubMed

  3. a) Jia, Z.-J.; Merten, C.; Gontla, R.; Daniliuc, C. G.; Antonchick, A. P.; Waldmann, H.. General Enantioselective C-H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angew. Chem. Int. Ed. Engl. 2017, 56 (9), 2429–2434.

    DOI PubMed

    b) Jia, Z.-J.; Merten, C.; Gontla, R.; Daniliuc, C. G.; Antonchick, A. P.; Waldmann, H.. General Enantioselective C−H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angew. Chem. 2017, 129 (9), 2469–2474.

    DOI

  4. Rauh, D.; Gontla, R.; Weisner, J. Kinase Inhbitors And Their Use In Cancer Therapy. European Patent EP 20150166458 20150505, May 5, 2015.
  5. a) Weisner, J.; Gontla, R.; van der Westhuizen, L.; Oeck, S.; Ketzer, J.; Janning, P.; Richters, A.; Mühlenberg, T.; Fang, Z.; Taher, A.; Jendrossek, V.; Pelly, S. C.; Bauer, S.; van Otterlo, W. A. L.; Rauh, D.. Covalent-Allosteric Kinase Inhibitors. Angew. Chem. Int. Ed. Engl. 2015, 54 (35), 10313–10316.

    DOI PubMed

    b) Weisner, J.; Gontla, R.; van der Westhuizen, L.; Oeck, S.; Ketzer, J.; Janning, P.; Richters, A.; Mühlenberg, T.; Fang, Z.; Taher, A.; Jendrossek, V.; Pelly, S. C.; Bauer, S.; van Otterlo, W. A. L.; Rauh, D.. Kovalent-allosterische Kinase-Inhibitoren. Angew. Chem. 2015, 127 (35), 10452–10456.

    DOI

  6. Chandrasekhar, S.; Gontla, R.; Naresh, T.. Enantioselective synthesis of the C5–C23 segment of biselyngbyaside. Tetrahedron Lett. 2013, 54 (3), 252–255.

    DOI

  7. Chandrasekhar, S.; Balaji, S. V.; Gontla, R.. First total synthesis of achaetolide. Tetrahedron Lett. 2010, 51 (39), 5164–5166.

    DOI

  8. Chandrasekhar, S.; Khatun, S.; Gontla, R.; Raji Reddy, C.. B(C6F5)3: an efficient catalyst for reductive alkylation of alkoxy benzenes and for synthesis of triarylmethanes using aldehydes. Tetrahedron Lett. 2009, 50 (48), 6693–6697.

    DOI

  9. Reddy, C. R.; Gontla, R.; Balaji, S. V.; Chethan, N.. Tris(pentafluorophenyl)borane: a mild and efficient catalyst for the chemoselective tritylation of alcohols. Tetrahedron Lett. 2008, 49 (6), 970–973.

    DOI