Ina Landel, M.Sc.
Position: PhD student
Room no.: CP-02-114
Telephone no.: +49 (0)231 755 7052
Member of the group since: 11/2016
University degree: M.Sc. in Chemical Biology, TU Dortmund University
Earlier positions: Bachelor and Master studies in the group of Daniel Rauh on protein expression and crystallization of EGFR and MKK7
Expertise: protein expression and purification, protein crystallization, cellular assays
Off-Lab activities (hobbies): piano, cooking, DIY projects
Structure-based design and optimization of compounds in medicinal chemistry requires the existence of protein crystal structures in particular in complex with different ligands. In the case of the protein kinase AKT, which shows aberrant activity in several cancer types, we developed the approach of covalent-allosteric AKT inhibitors (CAAIs). Therefore, crystallization studies revealing the covalent bond formation and validating the predicted binding mode, provide opportunities for further compound optimization. In addition to co-crystallization of AKT, cellular characterization of CAAIs in different cancer cell lines is part of my project.