Alina Teuber, M.Sc.
Room no.: CP-02-133
Telephone no.: +49 231 755 7052
Member of the group since: 07/2020
University Degree: M.Sc. in Chemical Biology, TU Dortmund University
Expertise: protein expression and purification, protein crystallization, biochemical evaluation
Off-Lab activities (hobbies): soccer, transverse flute, cooking
c-KIT and PDGFRα are the driving oncogenes in gastrointestinal stromal tumors. There are already accepted kinase inhibitors for treatment of these cancer diseases but development of secondary mutations leads to treatment resistances. For the structure-based design and optimization of new inhibitors crystal structures of the target proteins are necessary to achieve a deep insight into the protein in complex with the ligands. Such insights can lead to further compound optimization. Additionally the biochemical evaluation of the synthesized compounds on c-Kit- and PDGFRα mutants are part of my project.
Bachelor and Master studies in the group of Prof. Dr. Daniel Rauh on expression and crystallization of EGFR mutants, c-KIT and PDGFRα