Team
Team

Swantje Seifert

Position: PhD Student

Room no.: CP-02-132

Telephone no.: +49 (0)231 755 8833

Email: swantje.seifert@tu-dortmund.de

Member of the group since: 06/2015

University degree: M.Sc. in Chemical Biology, TU Dortmund University

 

Expertise: Design of Photoswitchable Proteins, in vitro Transcription, RNA

Off-Lab activities (hobbies): snowboarding, surfing, travel

Research projects:

The regulation of enzymatic activity is a major event in nature as well as in different scientific research areas like medicinal chemistry, molecular biology or biotechnology. Besides the control with small molecules (activators, inhibitors) it is shown that enzymatic activity can also be regulated by irradiation with light. In this project, we generate a light switchable model approach with the T7 RNA Polymerase as enzymatic effector and the Light-Oxygen-Voltage (LOV) domain as photosensor to design a photocontrollable DNA Transcription system in vitro and in vivo.