Position: PhD Student
Room no.: CP-02-112
Telephone no.: +49 (0)231 755 7056
Member of the group since: 11/2018
University Degree: M. Sc. in Chemical Biology, TU Dortmund University
Earlier positions: Bachelor and Master studies at Rauh group on synthesis and evaluation of allosteric kinase modulators and synthesis and evaluation of stapled peptides
Expertise: organic synthesis, biochemical and-physical methods, protein expression and purification, protein crystallization
Off-Lab activities (hobbies): athletics and weight lifting, reading, cooking
The protein kinases Akt1, Akt2, and Akt3 are highly conserved regulators within cellular signaling networks. They are involved in many processes such as proliferation, survival, and metabolism. Currently, the individual roles of the different isoforms in disease states are not completely understood, so there is a strong need for pharmacological perturbation studies to dissect the functional role of the individual Akt isoforms. We want to develop covalent-allosteric inhibitors with an ideal selectivity profile towards Akt isoforms and further functionalize those as potent probes, to eventually allow for the dissection of the biological functions of Akt1, Akt2, and Akt3.
Crystallization studies of the three isoforms revealing the covalent bond formation and validating the predicted binding mode, are essential to provide opportunities for further compound optimization. Also a strong focus of my project lies on the evaluation of these compounds in different cancer cell lines.